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Opioid-Free Perioperative Pain Protocol Is Noninferior to Opioid-Containing Management

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Ace Report Cover
June 2025

Opioid-Free Perioperative Pain Protocol Is Noninferior to Opioid-Containing Management

Vol: 307| Issue: 6| Number:17| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

An Opioid-Free Perioperative Pain Protocol Is Noninferior to Opioid-Containing Management: A Randomized Controlled Trial.

J Bone Joint Surg Am. 2025 Apr 2;107(7):665-677.

Contributing Authors:
R Turk B Averkamp K Hietpas C Michalek D Leas SM Odum N Hamid

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Synopsis

Three hundred fifteen patients undergoing five common elective orthopedic procedures were randomized to receive either an opioid-free perioperative pain management protocol (n=157) or an opioid-containing protocol (n=158). The primary outcome was the numeric rating scale (NRS) for pain at 24 hours postoperatively. Secondary outcomes included pain levels at other time points (6 and 12 hours; 2 week...

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