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S-Ketamine Reduces the Risk of Rebound Pain in Patients Following Total Knee Arthroplasty
May 2025
S-Ketamine Reduces the Risk of Rebound Pain in Patients Following Total Knee Arthroplasty
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
S-Ketamine Reduces the Risk of Rebound Pain in Patients Following Total Knee Arthroplasty: A Randomized Controlled Trial.
Drug Des Devel Ther . 2025 Mar 27:19:2315-2327.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Three hundred fifty-six adult patients undergoing total knee arthroplasty were randomized to receive a continuous intraoperative infusion of S-ketamine (n = 178) or placebo (n = 178). The primary outcome of interest was the incidence of rebound pain (RP) within 12 hours post-surgery. Secondary outcomes of interest included the incidence of RP within 24 hours, time to RP onset, time to first rescue...
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