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Efficacy Of Low-Dose Esketamine Weakly Opioidized Anesthesia In Elderly Patients Undergoing Surgery
May 2025
Efficacy Of Low-Dose Esketamine Weakly Opioidized Anesthesia In Elderly Patients Undergoing Surgery
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Safety and efficacy of low-dose esketamine weakly opioidized anesthesia in elderly patients with lumbar spinal stenosis undergoing surgery: a prospective, double-blind randomized controlled trial.
BMC Anesthesiol. 2025 Feb 5;25(1):57.Synopsis
Ninety elderly patients with lumbar spinal stenosis were randomized to receive high-dose esketamine (HS) (n=30), low-dose esketamine (LS) (n=30), or saline (control, C) (n=30) during total laminectomy and interbody fusion surgery. The primary outcome was the cumulative perioperative dose of sufentanil. Secondary outcomes included pain scores (VAS) at rest and during movement, serum inflammatory bi...
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