LOGIN
Dextrose Prolotherapy vs Saline for Knee Osteoarthritis: An Ultrasound-Guided RCT
September 2025
Dextrose Prolotherapy vs Saline for Knee Osteoarthritis: An Ultrasound-Guided RCT
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Comparison of the efficacy of ultrasound-guided dextrose 25% hypertonic prolotherapy and intra-articular normal saline injection on pain, functional limitation, and range of motion in patients with knee osteoarthritis; a randomized controlled trial.
BMC Musculoskelet Disord. 2025 Mar 31;26:313.Synopsis
Fifty patients with knee osteoarthritis were randomized to receive ultrasound-guided intra-articular dextrose prolotherapy (25% final concentration; n=25) or intra-articular normal saline (n=25), each as a single suprapatellar injection with lidocaine and standardized home exercises. The primary outcome was WOMAC (total and subscales). Secondary outcomes included VAS pain, Oxford Knee Score (OKS),...
To view the full content, login to your account,
or start your 30-day FREE Trial today.
FREE TRIAL
LOGIN
Forgot Password?
Explore some of our unlocked ACE Reports below!
Learn about our AI Driven
High Impact Search Feature
Our AI driven High Impact metric calculates the impact an article will have by considering both the publishing journal and the content of the article itself. Built using the latest advances in natural language processing, OE High Impact predicts an article’s future number of citations better than impact factor alone.
Continue
Join the Conversation
Please Login or Join to leave comments.