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The Role Of Tranexamic Acid And Cryotherapy On Acute Postoperative Pain And Blood Loss
October 2025
The Role Of Tranexamic Acid And Cryotherapy On Acute Postoperative Pain And Blood Loss
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
The role of tranexamic acid and cryotherapy on acute postoperative pain and blood loss: a randomized controlled study following total knee arthroplasty.
Eur J Orthop Surg Traumatol . 2025 Jan 25;35(1):58.Synopsis
Seventy-six patients with advanced knee osteoarthritis scheduled for primary unilateral total knee arthoplasty (TKA) were randomized to receive cryotherapy (n=26), intravenous tranexamic acid (TXA; n=25), or standard cold packs (control; n=25). The primary outcome of interest was acute postoperative blood loss (serial Hb/Hct). Secondary outcomes included VAS pain, knee flexion/extension, and coagu...
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