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Clinical Efficacy Of Cell-Free Fat Extract On Knee Osteoarthritis And Bone Marrow Edema

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May 2025

Clinical Efficacy Of Cell-Free Fat Extract On Knee Osteoarthritis And Bone Marrow Edema

Vol: 307| Issue: 5| Number:63| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Clinical efficacy of cell-free fat extract and its effects on bone marrow edema in patients with early to mid-stage knee osteoarthritis: a clinical trial in comparison with hyaluronic acid.

J Orthop Surg Res . 2025 Feb 9;20(1):153.

Contributing Authors:
C Zhang Y Lu Y Huang

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Synopsis

Forty-six patients with early to mid-stage knee osteoarthritis were randomized to receive either intra-articular CEFFE (n=26) or HA (n=26). Each group received five weekly injections of 2 ml. The primary outcome was clinical efficacy measured at 6 months, including VAS, WOMAC, and Lysholm scores. Secondary outcomes included MRI-based bone marrow edema grading at 6 months. Overall, the results reve...

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