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Combination of Pregabalin and Naproxen Superior to Naproxen in Reducing Pain in Ankle Fracture
March 2025
Combination of Pregabalin and Naproxen Superior to Naproxen in Reducing Pain in Ankle Fracture
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Is perioperative use of a combination of pregabalin and naproxen superior to naproxen only in reducing pain in ankle fractures? A prospective, randomized, multicenter study.
J Orthop Surg Res. 2024 Dec 26;19(1):882.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Seventy patients with rotatory ankle fractures were randomized to receive either naproxen alone (n=35) or naproxen plus pregabalin (n=35). The primary outcome was postoperative pain measured by the visual analog scale (VAS). Secondary outcomes included opioid consumption, adverse effects, and functional scores (Olerud and Molander Score, A-FORM) over a six-month follow-up. Overall, the results of ...
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