LOGIN
Low-Dose Duloxetine After TKA: Opioid-Sparing Without Added Pain Relief
September 2025
Low-Dose Duloxetine After TKA: Opioid-Sparing Without Added Pain Relief
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Does postoperative low-dose duloxetine provide analgesic effect and lower morphine consumption after primary total knee arthroplasty? A prospective, double-blind, randomized controlled trial.
Arch Orthop Trauma Surg . 2024 Nov;144(11):4979-4987.Synopsis
Eighty-four patients with primary knee osteoarthritis were randomized to receive duloxetine 30 mg daily for 6 weeks (n=42) or standard multimodal analgesia alone (n=42). The primary outcome was VAS pain at rest, during walking, and at night at 24 h, 72 h, 2 weeks, 6 weeks, and 12 weeks. Secondary outcomes were morphine use (0–72 h), adverse events, knee ROM, and function (OKS, KOOS). Overall, the ...
To view the full content, login to your account,
or start your 30-day FREE Trial today.
FREE TRIAL
LOGIN
Forgot Password?
Explore some of our unlocked ACE Reports below!
Learn about our AI Driven
High Impact Search Feature
Our AI driven High Impact metric calculates the impact an article will have by considering both the publishing journal and the content of the article itself. Built using the latest advances in natural language processing, OE High Impact predicts an article’s future number of citations better than impact factor alone.
Continue
Join the Conversation
Please Login or Join to leave comments.