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Safety and Efficacy of Pacental Cells Derived Extracellular Vesicles in Knee Osteoarthritis
January 2025
Safety and Efficacy of Pacental Cells Derived Extracellular Vesicles in Knee Osteoarthritis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Safety and efficacy of placental mesenchymal stromal cells-derived extracellular vesicles in knee osteoarthritis: a randomized, triple-blind, placebo-controlled clinical trial.
BMC Musculoskelet Disord . 2024 Oct 28;25(1):856.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Fifty-eight knees from 29 patients with grade 2 or 3 bilateral knee osteoarthritis were randomized in a split-body design to receive a single injection of PMSCs-EVs (n=29) or normal saline (n=29). The primary outcome of interest was improvement in clinical symptoms assessed by VAS, WOMAC, and Lequesne scores. Secondary outcomes included changes in MRI findings such as cartilage volume, meniscal di...
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