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Intrawound Vancomycin To Prevent Periprosthetic Joint Infection in Total Knee Arthroplasty
November 2024
Intrawound Vancomycin To Prevent Periprosthetic Joint Infection in Total Knee Arthroplasty
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Efficacy of Intrawound Vancomycin in Prevention of Periprosthetic Joint Infection After Primary Total Knee Arthroplasty: A Prospective Double-Blinded Randomized Control Trial.
J Arthroplasty . 2024 Jun;39(6):1569-1576.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
1,022 patients with primary knee osteoarthritis were randomized to receive either 2 grams of intrawound vancomycin powder (n=507) or no vancomycin (control, n=515) before arthrotomy closure. The primary outcome of interest was the incidence of periprosthetic joint infection (PJI) or surgical site infection (SSI). Secondary outcomes included rates of minor wound complications, reoperation rates, an...
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