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Intra-articular Injections of Hylan G-F 20 for Pain in Patients with Idiopathic Knee Osteoarthritis

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Ace Report Cover
December 2024

Intra-articular Injections of Hylan G-F 20 for Pain in Patients with Idiopathic Knee Osteoarthritis

Vol: 306| Issue: 12| Number:36| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Three once-weekly intra-articular injections of Hylan G-F 20 significantly improve pain relief compared with placebo in patients with chronic idiopathic knee osteoarthritis: a single-centre, evaluator-blinded and patient-blinded, randomized controlled tri

Drugs Context. 2024 01-Apr;():. 10.7573/dic.2023-11-3

Contributing Authors:
M Langworthy P Lascarides W Ngai K Steele Y Huang

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Synopsis

Thirty patients with chronic idiopathic knee osteoarthritis (Larsen grade II or III) were randomized to receive three once-weekly intra-articular injections of either Hylan G-F 20 (n=15) or placebo (n=15). The primary outcome was pain relief as assessed by visual analogue scale (VAS) scores at weeks 12 and 26. Secondary outcomes included patient activity level, overall clinical condition, and adve...

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