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Vancomycin & Cefazolin Surgical Antibiotic Prophylaxis: The ASAP Trial
May 2024
Vancomycin & Cefazolin Surgical Antibiotic Prophylaxis: The ASAP Trial
Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A
Multicentre randomised double-blind placebo controlled trial of combintion vancomycin and cefazolin surgical antibiotic prophylaxis: the Australian surgical antibiotic prophylaxis (ASAP) trial
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CONFERENCE ACE REPORTS
This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.
Synopsis
Four thousand two hundred thirty-nine patients undergoing joint replacement surgery were randomized to receive either vancomycin plus cefazolin (n=2044) or cefazolin plus placebo (n=2069). The primary outcome was the incidence of surgical site infections within 90 days. Secondary outcomes included hypersensitivity reactions, acute kidney injury, and other adverse events. Outcomes were assessed up ...
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