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Vancomycin & Cefazolin Surgical Antibiotic Prophylaxis: The ASAP Trial

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Ace Report Cover
May 2024

Vancomycin & Cefazolin Surgical Antibiotic Prophylaxis: The ASAP Trial

Vol: 306| Issue: 5| Number:108| ISSN#: 2564-2537
Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A

Multicentre randomised double-blind placebo controlled trial of combintion vancomycin and cefazolin surgical antibiotic prophylaxis: the Australian surgical antibiotic prophylaxis (ASAP) trial

Contributing Authors:
S Adie TN Peel S Astbury AL Cheng DL Paterson KL Buising T Spelman G Boyce C McDougall R Molnar V Steiger Group ASAP Trial

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CONFERENCE ACE REPORTS

This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.

Synopsis

Four thousand two hundred thirty-nine patients undergoing joint replacement surgery were randomized to receive either vancomycin plus cefazolin (n=2044) or cefazolin plus placebo (n=2069). The primary outcome was the incidence of surgical site infections within 90 days. Secondary outcomes included hypersensitivity reactions, acute kidney injury, and other adverse events. Outcomes were assessed up ...

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