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Cell Therapy With Autologous Bone Marrow Cells for Plate-Stabilized Proximal Humerus Fractures

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Ace Report Cover
June 2025

Cell Therapy With Autologous Bone Marrow Cells for Plate-Stabilized Proximal Humerus Fractures

Vol: 307| Issue: 6| Number:82| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Cell-Based Therapy by Autologous Bone Marrow-Derived Mononuclear Cells for Bone Augmentation of Plate-Stabilized Proximal Humeral Fractures: A Multicentric, Randomized, Open Phase IIa study.

Stem Cells Transl Med . 2024 Jan 12;13(1):3-13.

Contributing Authors:
C Seebach C Nau D Henrich R Verboket M Bellen N Frischknecht V Moeck K Eichler KHS Horlohe R Hoffmann H Bonig E Seifried J Frank I Marzi

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Synopsis

Ninety four patients with proximal humerus fractures were randomized to receive either autologous bone marrow-derived mononuclear cells (BMC) on a β-tricalcium phosphate (β-TCP) scaffold (n=47) or β-TCP scaffold alone (n=47) during surgical fixation with an angular stable plate. Outcomes were evaluated over 12 weeks. The study assessed radiographic healing and functional shoulder recovery (DASH sc...

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