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Volume:1 Issue:3 Number:189 ISSN#:2563-5476
RCT
ACE Report #167
Ace Report Cover Arthroplasty

Apixiban more effective than enoxaparin for prevention of postoperative thromboembolism


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): A randomised double-blind trial

Lancet. 2010 Mar 6;375(9717):807-15.

Contributing Authors: MR Lassen GE Raskob A Gallus G Pineo D Chen P Hornick ADVANCE-2 investigatorsCollaborators (181)

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Synopsis

3057 patients scheduled for an elective unilateral or same-day bilateral total knee replacement were randomized to the drug used in prevention of venous thromboembolism, either oral apixiban or subcutaneous enoxaparin. 60 days after the final dose apixiban when compared to enoxaparin was found to be more effective in preventing thrombosis events, had lesser bleeding risks, and had the convenience ...

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