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Core Decompression With or Without Autologous Osteoblastic Cells in Early Femoral Head Osteonecrosis
September 2025
Core Decompression With or Without Autologous Osteoblastic Cells in Early Femoral Head Osteonecrosis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Does Adjunction of Autologous Osteoblastic Cells Improve the Results of Core Decompression in Early-stage Femoral Head Osteonecrosis? A Double-blind, Randomized Trial.
Clin Orthop Relat Res . 2023 Aug 1;481(8):1527-1540.Synopsis
Fifty-four patients with precollapse osteonecrosis of the femoral head (ONFH) were randomized to core decompression plus autologous osteoblastic cells (n=25) or core decompression plus placebo (n=29). The primary outcome was a composite 24-month “treatment response” (WOMAC pain improvement ≥10 mm and no radiographic progression to ≥ARCO III). Secondary outcomes included the same composite at 12 mo...
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