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Tourniquet Use in TKA Increases Infrapatellar Fat Pad Cellular Injury
September 2025
Tourniquet Use in TKA Increases Infrapatellar Fat Pad Cellular Injury
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
An investigation into the cellular-level adverse effects of tourniquet use on the infrapatellar fat pad in primary total knee arthroplasty: A prospective randomized study.
Acta Orthop Traumatol Turc . 2023 Sep;57(5):283-288.Synopsis
Eighty knees from fifty-eight patients with end-stage osteoarthritis were randomized to TKA with a tourniquet (n=40 knees) or without a tourniquet (n=40 knees). The primary outcomes were cellular markers in IPFP sampled intraoperatively: hypoxia (HIF-1α H-score), apoptosis (BAX/Bcl-2 ratio), and oxidative stress (oxidative stress index, OSI). Secondary outcomes included ROM and patient-reported/cl...
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