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Preventing Pregabalin Side Effect Before Total Joint Arthroplasty
December 2025
Preventing Pregabalin Side Effect Before Total Joint Arthroplasty
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Prevention of Pregabalin-Related Side Effects Using Slow Dose Escalation Before Surgery: A Trial in Primary Total Joint Arthroplasty Within the Enhanced Recovery After Surgery Pathway.
J Arthroplasty. 2023 01-Aug;():. 10.1016/j.arth.2023.01.039Synopsis
Fifty-eight adults undergoing primary total hip arthroplasty (THA) or total knee arthroplasty (TKA) were randomized to pregabalin slow-dose escalation or single preoperative pregabalin dose alone. All patients received 75 mg pregabalin two hours before incision, but only one group (G1) received 37.5 mg twice the day before surgery, while the other (G2) received none. The primary outcome was postop...
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