Vancomycin & Cefazolin for Infection Prophylaxis in Arthroplasty: A Randomized Trial
Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in ArthroplastyN Engl J Med. 2023 Oct 19;389(16):1488-1498.
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4,239 patients undergoing an arthroplasty surgery were randomized to received infection prophylaxis with vancomycin and cefazolin (n=2,118) or cefazolin alone (n=2,121). The primary outcome of interest was the incidence of surgical site infection at 90 days post-operation. Secondary outcomes of interest included superficial, deep, and organ-space infection; deep or organ-spaced infections between ...
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