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Vancomycin & Cefazolin for Infection Prophylaxis in Arthroplasty: A Randomized Trial
November 2023
Vancomycin & Cefazolin for Infection Prophylaxis in Arthroplasty: A Randomized Trial
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in Arthroplasty
N Engl J Med. 2023 Oct 19;389(16):1488-1498.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
4,239 patients undergoing an arthroplasty surgery were randomized to received infection prophylaxis with vancomycin and cefazolin (n=2,118) or cefazolin alone (n=2,121). The primary outcome of interest was the incidence of surgical site infection at 90 days post-operation. Secondary outcomes of interest included superficial, deep, and organ-space infection; deep or organ-spaced infections between ...
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