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Duloxetine on Opioid Consumption and Pain After Total Joint Arthroplasty: A Meta-Analysis
February 2024
Duloxetine on Opioid Consumption and Pain After Total Joint Arthroplasty: A Meta-Analysis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Effect of duloxetine on opioid consumption and pain after total knee and hip arthroplasty: a systematic review and meta-analysis of randomized clinical trials.
Pain Med . 2023 Sep 1;24(9):1035-1045.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Nine randomized controlled trials (806 patients) comparing the effect of duloxetine against a control in patients undergoing total hip or knee replacement (THA & TKA, respectively) were included in this systematic review and meta-analysis. Outcomes of interest included total opioid consumption, pain at rest and with activity on a Normalized Pain Scale (NPS), and the incidence of adverse events. Op...
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