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Fentanyl and Bupivacaine Infusions for Patients with Chronic Back Pain
December 2025
Fentanyl and Bupivacaine Infusions for Patients with Chronic Back Pain
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Efficacy of Continuous Intrathecal Infusion Trialing with a Mixture of Fentanyl and Bupivacaine in Chronic Low Back Pain Patients.
Pain Med. 2023 01-Jul;():. 10.1093/pm/pnac195Synopsis
Thirty-six patients with refractory chronic low back pain were randomized to receive either intrathecal fentanyl/bupivacaine followed by saline or the reverse sequence, with each infusion delivered continuously for 14–18 hours and separated by a 6-hour saline washout. The primary outcome was the change in Numerical Rating Scale (NRS) pain scores from baseline to the end of each infusion. Overall, ...
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