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Intravenous Unit-Dose Tranexamic Acid for Blood Loss Management in Posterior Lumbar Interbody Fusion
May 2023
Intravenous Unit-Dose Tranexamic Acid for Blood Loss Management in Posterior Lumbar Interbody Fusion
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
The effect of intravenous unit-dose tranexamic acid on visible and hidden blood loss in posterior lumbar interbody fusion: a randomized clinical trial.
Sci Rep. 2023 Mar 22;13(1): 4714.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
100 patients undergoing a posterior lumbar interbody fusion procedure were randomized to receive a unit dose of intravenous tranexamic acid 15 minutes before skin incision (n=50) or normal saline (n=50). The outcomes of interest included operative time, blood loss, drainage volume, transfusion rate, events, coagulation and inflammatory markers. Biomarkers were measured at 1 and 4 days post-operati...
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