Safety and Efficacy of Duloxetine after Total Knee Arthroplasty: A Meta-Analysis
Effect of duloxetine on pain relief after total knee arthroplasty: A meta-analysis of randomized controlled trials.Medicine (Baltimore) . 2023 Mar 10;102(10):e33101.
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In this meta-analysis, six randomized controlled trials compared duloxetine against placebo in patients undergoing primary total knee arthroplasty (TKA). Outcomes of interest were pain measured on a Visual Analog Scale (VAS) at rest and with movement, equivalent morphine consumption, length of stay, and adverse events. Pain scores with movement favored duloxetine at 24 and 72 hours, and 5 days, wh...
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