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Celecoxib + Pregabalin for Managing Postoperative Analgesia in Patients Undergoing TKA
December 2023
Celecoxib + Pregabalin for Managing Postoperative Analgesia in Patients Undergoing TKA
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Positive Preemptive Analgesia Effectiveness of Pregabalin Combined with Celecoxib in Total Knee Arthroplasty: A Prospective Controlled Randomized Study.
Pain Res Manag . 2023 Jan 12:2023:7088004.Synopsis
160 patients with knee osteoarthritis, undergoing total knee arthroplasty were randomized to receive either pregabalin + celecoxib (n=40), celecoxib alone (n=40), pregabalin alone (n=40), or placebo (n=40). Outcomes of interest included pain at rest and with movement on a Visual Analog Scale (VAS), sufentanil cumulative dose, high-sensitivity C-reactive protein (hs-CRP), range of motion (ROM), and...
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