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Ace Report Cover

Low-Dose vs. High-Dose Tranexamic Acid in Adult Spinal Deformity Surgery

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Ace Report Cover
December 2022

Low-Dose vs. High-Dose Tranexamic Acid in Adult Spinal Deformity Surgery

Vol: 302| Issue: 4| Number:18| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Randomized, controlled trial of two tranexamic acid dosing protocols in adult spinal deformity surgery

Spine Deform. 2022 Nov;10(6):1399-1406.

Contributing Authors:
JCF Clohisy LG Lenke MHE Dafrawy RC Wolfe E Frazier MP Kelly

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Synopsis

Fifty-two adults undergoing multi-level fusion surgery for adult spinal deformity were randomized to receive a high-dose tranexamic acid regimen (n=25) or a low-dose tranexamic acid regimen (n=27) for the minimization of blood loss. Outcomes of interest included estimated blood loss, blood loss as a percentage of body volume, transfusion volume, and length of stay, and the incidence of complicatio...

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