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NO PAin Trial: Multimodal Opioid-Sparing Approach for Pain Control After Knee/Shoulder Arthroscopy

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Ace Report Cover
January 2000

NO PAin Trial: Multimodal Opioid-Sparing Approach for Pain Control After Knee/Shoulder Arthroscopy

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Effect of a postoperative multimodal opioid-sparing protocol vs standard opioid prescribing on postoperative opioid consumption after knee or shoulder arthroscopy

JAMA. 2022 Oct 4;328(13): 1326-1335.

Contributing Authors:
The NO PAin Investigators A Gazendam S Ekhtiari NS Horner N Simunovic M Khan DL de Sa K Madden OR Ayeni

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Synopsis

Two hundred patients undergoing shoulder or knee arthroscopy were randomized to receive an opioid-sparing pain management protocol (n=100) or the standard-of-care pain management protocol (n=100). The primary outcome of interest was postoperative opioid consumption in oral morphine equivalents. Secondary outcomes of interest included pain, patient satisfaction, opioid prescription/refill, and the ...

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