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Aqueous-PREP Trial: Aqueous Skin Antisepsis Prior to Surgical Fixation of Open Fractures
October 2022
Aqueous-PREP Trial: Aqueous Skin Antisepsis Prior to Surgical Fixation of Open Fractures
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial
Lancet. 2022 01-Aug;():.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
1683 patients from 14 hospitals in Canada, Spain and the United States were included in this cluster-based randomized crossover trial comparing aqueous 10% povidone-iodine vs. 4% chlorhexidine gluconate for skin antisepsis in patients undergoing open fracture surgery. The primary outcome of interest was the risk of surgical site infection. The secondary outcome of interest was the rate of unplanne...
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