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Vol:236 Issue:1 Number:1 ISSN#:2564-2537
ACE Report #14629
Ace Report Cover Osteoarthritis

Intramuscular vs. Intra-articular Glucocorticoid Injection for Knee Osteoarthritis

How to Cite

OrthoEvidence. Intramuscular vs. Intra-articular Glucocorticoid Injection for Knee Osteoarthritis. ACE Report. 2022;236(1):1. Available from:

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Effect of Intramuscular vs Intra-articular Glucocorticoid Injection on Pain Among Adults With Knee Osteoarthritis: The KIS Randomized Clinical Trial.

JAMA Netw Open . 2022 Apr 1;5(4):e224852.

Contributing Authors:
Q Wang MF Mol PK Bos DMJ Dorleijn M Vis J Gussekloo PJE Bindels J Runhaar SMA Bierma-Zeinstra

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One hundred and forty-five patients with knee osteoarthritis were randomized in this non-inferiority trial to receive an intramuscular glucocorticoid injection (n=74) or an intra-articular glucocorticoid injection (n=71). The primary outcome of interest was pain at 4 weeks as measured with the Knee Injury and Osteoarthritis Outcome Score (KOOS) pain sub-scale. Secondary outcomes included KOOS pain...

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