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The POISE-3 Trial: Tranexamic Acid in Patients Undergoing Noncardiac Surgery
April 2022
The POISE-3 Trial: Tranexamic Acid in Patients Undergoing Noncardiac Surgery
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Tranexamic Acid in Patients Undergoing Noncardiac Surgery
N Engl J Med. 2022 Apr 2.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
9535 patients undergoing non-cardiac surgery were randomized to receive tranexamic acid (n=4757) or placebo (n=4778) at the start and end of surgery. The primary efficacy outcome was a composite bleeding outcome of life-threatening bleeding, major bleeding, or bleeding into a critical organ. The primary safety outcome was a composite endpoint of myocardial injury, non-hemorrhagic stroke, periphera...
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