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General Orthopaedics

The POISE-3 Trial: Tranexamic Acid in Patients Undergoing Noncardiac Surgery

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April 2022
General Orthopaedics

The POISE-3 Trial: Tranexamic Acid in Patients Undergoing Noncardiac Surgery

Vol: 224| Issue: 2| Number:1| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Tranexamic Acid in Patients Undergoing Noncardiac Surgery

N Engl J Med. 2022 Apr 2.

Contributing Authors:
PJ Devereaux M Marcucci TW Painter D Conen V Lomivotrov DI Sessler MTV Chan FK Borges MJ Martinez-Zapata CY Wang D Xavier SN Ofori M Wang S Efremov G Landoni YV Kleinlugtenbelt W Szczeklik D Schmartz AX Garg TG Short M Wittmann CS Meyhoff M Amir D Torres A Patel E Duceppe K Ruetzler JL Parlow V Tandon E Fleischmann CA Polanczyk A Lamy SV Astrakov WK Wu K Bhatt M de Nadal VV Likhvantsev P Paniagua HJ Aguado RP Whitlock MH McGillion M Prystajecky J Vincent J Eikelboom I Copland K Balasubramanian A Turan SI Bangdiwala D Stillo P Gross T Cafaro P Alfonsi PS Roshanov EP Belley-Côté J Spence T Richards T VanHelder W McIntyre G Guyatt S Yusuf K Leslie POISE-3 Investigators

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Synopsis

9535 patients undergoing non-cardiac surgery were randomized to receive tranexamic acid (n=4757) or placebo (n=4778) at the start and end of surgery. The primary efficacy outcome was a composite bleeding outcome of life-threatening bleeding, major bleeding, or bleeding into a critical organ. The primary safety outcome was a composite endpoint of myocardial injury, non-hemorrhagic stroke, periphera...

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