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Vol:180 Issue:1 Number:1 ISSN#:2564-2537
ACE Report #14274
Ace Report Cover Osteoarthritis

Platelet-Rich Plasma Does Not Improve Pain or Cartilage Volume in Knee Osteoarthritis

How to Cite

OrthoEvidence. Platelet-Rich Plasma Does Not Improve Pain or Cartilage Volume in Knee Osteoarthritis . ACE Report. 2022;180(1):1. Available from:

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial.

JAMA . 2021 Nov 23;326(20):2021-2030.

Contributing Authors:
KL Bennell KL Paterson BR Metcalf V Duong J Eyles J Kasza Y Wang F Cicuttini R Buchbinder A Forbes A Harris SP Yu D Connell J Linklater BH Wang WM Oo DJ Hunter

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Two hundred and eighty eight patients with mild to moderate knee osteoarthritis (OA) were randomized to receive 3 intra-articular injections of leukocyte-poor platelet-rich plasma (PRP, n=144) or a placebo injection (n=144). The primary outcomes of interest were subjective pain scores and percentage change in medial tibial cartilage volume. Secondary outcomes of interest evaluated pain, function, ...

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