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Platelet-Rich Plasma Does Not Improve Pain or Cartilage Volume in Knee Osteoarthritis
February 2022
Platelet-Rich Plasma Does Not Improve Pain or Cartilage Volume in Knee Osteoarthritis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial.
JAMA . 2021 Nov 23;326(20):2021-2030.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Two hundred and eighty eight patients with mild to moderate knee osteoarthritis (OA) were randomized to receive 3 intra-articular injections of leukocyte-poor platelet-rich plasma (PRP, n=144) or a placebo injection (n=144). The primary outcomes of interest were subjective pain scores and percentage change in medial tibial cartilage volume. Secondary outcomes of interest evaluated pain, function, ...
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