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Vol:170 Issue:1 Number:1 ISSN#:2564-2537
ACE Report #14229
Ace Report Cover Trauma

Strong vs. Weak Opioids For Outpatient Analgesia After Surgically Managed Fractures

How to Cite

OrthoEvidence. Strong vs. Weak Opioids For Outpatient Analgesia After Surgically Managed Fractures. ACE Report. 2022;170(1):1. Available from:

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Effectiveness of Oxycodone Hydrochloride (Strong Opioid) vs Combination Acetaminophen and Codeine (Mild Opioid) for Subacute Pain After Fractures Managed Surgically: A Randomized Clinical Trial.

JAMA Netw Open . 2021 Nov 1;4(11):e2134988.

Contributing Authors:
DE Jenkin JM Naylor J Descallar IA Harris

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One hundred and twenty patients undergoing surgical fixation of fractures were randomized to receive a strong opioid (Oxycodone, n=59) or a weak opioid (Acetaminophen and codeine, n=61) at the time of discharge from hospital. The primary outcome of interest was mean pain scores for the first week after discharge from hospital as measured by the Numerical Pain Rating Scale (NPRS). Secondary outcome...

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