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Volume:111 Issue:1 Number:2 ISSN#:2564-2537
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ACE Report #13976
Ace Report Cover Osteoarthritis

Diclofenac-Hyaluronate Conjugate Injection for Knee Osteoarthritis


How to Cite

OrthoEvidence. Diclofenac-Hyaluronate Conjugate Injection for Knee Osteoarthritis . ACE Report. 2021;111(1):2. Available from: https://myorthoevidence.com/AceReport/Report/13976

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Efficacy and Safety of Diclofenac-Hyaluronate Conjugate (Diclofenac Etalhyaluronate) for Knee Osteoarthritis: A Randomized Phase III Trial in Japan.

Arthritis Rheumatol. 2021 Sep;73(9): 1646-1655.

Contributing Authors: Y Nishida K Kano Y Nobuoka T Seo

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Synopsis

Four hundred and forty patients with knee osteoarthritis were randomized to receive a series of intra-articular diclofenac-hyaluronate conjugate (Diclofenac Etalhyaluronate) injections (DF-HA) (n=220) or placebo injections (n=220). The primary outcome of interest was the change in baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale. Secondary outcom...

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