Visit our Evidence-Based Covid-19 Website and Stay Up to Date with the latest Research.
Volume:111 Issue:1 Number:2 ISSN#:2564-2537
ACE Report #13976
Ace Report Cover Osteoarthritis

Diclofenac-Hyaluronate Conjugate Injection for Knee Osteoarthritis

How to Cite

OrthoEvidence. Diclofenac-Hyaluronate Conjugate Injection for Knee Osteoarthritis . ACE Report. 2021;111(1):2. Available from: https://myorthoevidence.com/AceReport/Report/13976

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Efficacy and Safety of Diclofenac-Hyaluronate Conjugate (Diclofenac Etalhyaluronate) for Knee Osteoarthritis: A Randomized Phase III Trial in Japan.

Arthritis Rheumatol. 2021 Sep;73(9): 1646-1655.

Contributing Authors: Y Nishida K Kano Y Nobuoka T Seo

Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here


Four hundred and forty patients with knee osteoarthritis were randomized to receive a series of intra-articular diclofenac-hyaluronate conjugate (Diclofenac Etalhyaluronate) injections (DF-HA) (n=220) or placebo injections (n=220). The primary outcome of interest was the change in baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale. Secondary outcom...

CME Image

Continuing Medical Education Credits

You could be earning 0.5 CME credits for each report you read.

For Reprints and Permissions, click here

Please Login or Join to leave comments.