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Vol:49 Issue:1 Number:1 ISSN#:2564-2537
ACE Report #13685
Ace Report Cover Arthroplasty

Oral Duloxetine Reduces Pain During Movement & At Rest Up to 3 Weeks Post-THA vs Placebo

How to Cite

OrthoEvidence. Oral Duloxetine Reduces Pain During Movement & At Rest Up to 3 Weeks Post-THA vs Placebo. ACE Report. 2021;49(1):1. Available from:

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Duloxetine reduces pain after Total hip arthroplasty: a prospective, randomized controlled study

BMC Musculoskelet Disord . 2021 May 28;22(1):492

Contributing Authors:
H Li WN Zeng ZC Ding MC Yuan YR Cai ZK Zhou

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Ninety-six patients scheduled to undergo a primary, unilateral total hip arthroplasty (THA) were randomized to receive daily doses of 60 mg of oral duloxetine (n=48) or placebo (starch; n=48) at 2 days pre-surgery until 14 days post-surgery. The primary outcome of interest included pain during movement on the visual analogue scale (VAS) measured at 3 hours, 6 hours, 12 hours, 1 day, 2 day, 3 days,...

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