No Clinical Benefit of 12 Weeks of Daily Oral Colchicine vs Placebo for Hand Osteoarthritis

How to Cite

OrthoEvidence. No Clinical Benefit of 12 Weeks of Daily Oral Colchicine vs Placebo for Hand Osteoarthritis. ACE Report. 2021;17(1):4. Available from: https://myorthoevidene.com/AceReport/Report/13359

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:1

Colchicine is not effective for reducing osteoarthritic hand pain compared to placebo: a randomised, placebo-controlled trial (COLAH)

Osteoarthritis Cartilage. 2021 Feb;29(2): 208-214.

Contributing Authors: CR Davis Cd Ruediger KA Dyer S Lester SW Graf FPB Kroon SL Whittle CL Hill

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Synopsis

Sixty-four elderly patients diagnosed with hand osteoarthritis (OA) were randomized to receive 1 mg/day of colchicine (n=32) tablets or placebo tablets (n=32) for 12 weeks. The primary outcome of interest included hand pain measured using the Visual Analogue Scale (VAS), assessed at 6, 12 and 16 weeks follow-up. Secondary outcomes of interest included hand grip strength, tender and swollen joint (...