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Double IA Injection of Umbilical-Cord Derived MSCs Improves Pain vs Hyaluronic Acid for Knee OA
April 2021
Double IA Injection of Umbilical-Cord Derived MSCs Improves Pain vs Hyaluronic Acid for Knee OA
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial
Stem Cells Transl Med . 2019 Mar;8(3):215-224Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Twenty-nine patients with symptomatic knee osteoarthritis (OA) without meniscal rupture were randomized to receive to receive one of the three knee intra-articular injections: hyaluronic acid (HA) at baseline and 6 months follow-up; umbilical-cord (UC)-derived mesenchymal stromal cells (MSCs) at baseline and 6 months follow-up (MSC-1 group; n=10); UC-MSCs at baseline followed-up by placebo at 6 mo...
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