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Volume:8 Issue:9 Number:19 ISSN#:2563-5476
Author Verified
RCT
ACE Report #12327
Ace Report Cover General Orthopaedics

Addition of Rifampin to Antimicrobial Therapy Does Not Improve Success Rate in Staphylococcal PJI


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Rifampin combination therapy in staphylococcal prosthetic joint infections: a randomized controlled trial.

J Orthop Surg Res. 2020; 15: 365.

Contributing Authors: OE Karlsen P Borgen B Bragnes W Figved B Grogaard J Rydinge L Sandberg F Snorrason H Wangen E Witsoe M Westberg

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Synopsis

Sixty-five patients with staphylococcal peri-prosthetic joint infections of the hip or knee were randomized to receive debridement and wound excision plus 6 weeks of antimicrobial therapy (intravenous cloxacillin or vancomycin), with or without the addition of oral rifampin. The outcome of interest was treatment success at 2 years follow up, defined as a lack of clinical signs of peri-prosthetic j...

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