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Addition of Rifampin to Antimicrobial Therapy Does Not Improve Success Rate in Staphylococcal PJI
September 2020
Addition of Rifampin to Antimicrobial Therapy Does Not Improve Success Rate in Staphylococcal PJI
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Rifampin combination therapy in staphylococcal prosthetic joint infections: a randomized controlled trial.
J Orthop Surg Res. 2020; 15: 365.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Sixty-five patients with staphylococcal peri-prosthetic joint infections of the hip or knee were randomized to receive debridement and wound excision plus 6 weeks of antimicrobial therapy (intravenous cloxacillin or vancomycin), with or without the addition of oral rifampin. The outcome of interest was treatment success at 2 years follow up, defined as a lack of clinical signs of peri-prosthetic j...
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