Slight improvement in response with temozolamide plus radiotherapy vs radiotherapy alone for STS

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:1

Radiotherapy alone with concurrent chemoradiotherapy plus temozolamide in locally advanced soft tissue sarcoma at Mayo Hospital Lahore: A randomized controlled trial.

JPMA 70: 572. 2020 Apr 1;1:3-1.

Contributing Authors: MA Khokhar M Akhtar SFUHS Gillani R Abdulsalaam S Qamar

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Synopsis

Sixty-four patients with soft tissue sarcomas (STS) were randomized to receive radiation therapy only or radiation therapy plus oral temozolomide. The primary outcome of interest was treatment response as measured by the Response Evaluation Criteria in Solid Tumours (RECIST) criteria. Secondary outcomes of interest included the incidence of adverse events. Results revealed a significantly higher i...