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Denosumab in THA prevents early periprosthetic bone loss, effects diminish after treatment cessation

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Ace Report Cover
March 2020

Denosumab in THA prevents early periprosthetic bone loss, effects diminish after treatment cessation

Vol: 9| Issue: 3| Number:11| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Denosumab Prevents Early Periprosthetic Bone Loss After Uncemented Total Hip Arthroplasty: Results from a Randomized Placebo-Controlled Clinical Trial.

J Bone Miner Res. 2020 Feb;35(2):239-247.

Contributing Authors:
J Milbrink NP Hailer H Mallmin A Nystrom D Kiritopoulos G Ullmark J Sorensen M Petren-Mallmin

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Synopsis

Sixty-four patients scheduled for an uncemented total hip arthroplasty (THA) were randomized to receive either two doses of denosumab or placebo administered following completion of the procedure and 6 months post-operation. The primary outcomes of interest were bone mineral density (BMD) at Gruen zone 7 and the sum of BMDs in Gruen zones 1-7. Secondary outcomes of interest included standard uptak...

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