Denosumab in THA prevents early periprosthetic bone loss, effects diminish after treatment cessation
Denosumab in THA prevents early periprosthetic bone loss, effects diminish after treatment cessation
Denosumab Prevents Early Periprosthetic Bone Loss After Uncemented Total Hip Arthroplasty: Results from a Randomized Placebo-Controlled Clinical Trial.
J Bone Miner Res. 2020 Feb;35(2):239-247.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Sixty-four patients scheduled for an uncemented total hip arthroplasty (THA) were randomized to receive either two doses of denosumab or placebo administered following completion of the procedure and 6 months post-operation. The primary outcomes of interest were bone mineral density (BMD) at Gruen zone 7 and the sum of BMDs in Gruen zones 1-7. Secondary outcomes of interest included standard uptak...
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