Visit our Evidence-Based Covid-19 Website and Stay Up to Date with the latest Research.
Volume:7 Issue:12 Number:3 ISSN#:2563-5476
ACE Report #12081
Ace Report Cover Arthroplasty

Noninferiority of low-intensity to standard-intensity warfarin in geriatric hip or knee arthroplasty

Study Type:Randomized Trial
OE Level Evidence:2
Journal Level of Evidence:N/A

Effect of Low-Intensity vs Standard-Intensity Warfarin Prophylaxis on Venous Thromboembolism or Death Among Patients Undergoing Hip or Knee Arthroplasty: A Randomized Clinical Trial

JAMA. 2019 Sep 3;322(9):834-842.

Contributing Authors: BF Gage AR Bass H Lin SC Woller SM Stevens N Al-Hammadi JL Anderson J Li T Rodriguez JP Miller GA McMillin RC Pendleton AK Jaffer CR King B Whipple R Porche-Sorbet L Napoli K Merritt AM Thompson G Hyun W Hollomon RL Barrack RM Nunley G Moskowitz V Davila-Roman CS Eby

Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here


1650 elderly patients undergoing a hip or knee arthroplasty were randomized to receive a low-intensity dose (International Normalized Ratio (INR) = 1.8) or standard-intensity dose (INR = 2.5) of warfarin for the prevention of thromboembolic events. The primary outcome of interest was the composite outcome of VTE and death. Secondary outcomes of interest included the rate of major bleeding and the ...

To view the full report, start your 30-day free trial today

No credit card required

JOIN Forgot Password?

Not sure if you want to join OrthoEvidence?

Access this report without an Account.

Success, an email containing a link to access this report has been sent to your inbox.

CME Image

Continuing Medical Education Credits

You could be earning 0.5 CME credits for each report you read.


Please Login or Join to leave comments.