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Noninferiority of low-intensity to standard-intensity warfarin in geriatric hip or knee arthroplasty
December 2019
Noninferiority of low-intensity to standard-intensity warfarin in geriatric hip or knee arthroplasty
Study Type:Randomized Trial
OE Level Evidence:2
Journal Level of Evidence:N/A
Effect of Low-Intensity vs Standard-Intensity Warfarin Prophylaxis on Venous Thromboembolism or Death Among Patients Undergoing Hip or Knee Arthroplasty: A Randomized Clinical Trial
JAMA. 2019 Sep 3;322(9):834-842.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
1650 elderly patients undergoing a hip or knee arthroplasty were randomized to receive a low-intensity dose (International Normalized Ratio (INR) = 1.8) or standard-intensity dose (INR = 2.5) of warfarin for the prevention of thromboembolic events. The primary outcome of interest was the composite outcome of VTE and death. Secondary outcomes of interest included the rate of major bleeding and the ...
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