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Meta-analysis
ACE Report #12057
Ace Report Cover General Orthopaedics

Low-dose ketamine reduces pain and opioid consumption following orthopaedic surgery


Study Type:Meta-analysis/Systematic Review
OE Level Evidence:1
Journal Level of Evidence:N/A

Low-dose ketamine in painful orthopaedic surgery: a systematic review and meta-analysis

Br J Anaesth. 2019 Sep;123(3):325-334.

Contributing Authors: JM Riddell JM Trummel IJ Onakpoya

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Synopsis

Twenty studies with 1271 patients were included in this systematic review and meta-analysis comparing low-dose ketamine to normal saline in patients undergoing surgical orthopaedic procedures. The primary outcomes of interest were total opioid consumption, time to first opioid administration and pain scores. Secondary outcomes of interest included the incidences of post-operative nausea and vomiti...

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