OTA 2019: Improved bone healing with PLEX-DBG over control in open fracture surgery

Study Type:N/A

OE Level Evidence:N/A

Journal Level of Evidence:N/A

Improved Healing of Severe Open Long Bone Fractures Treated with AntibioticFormulated Bone Graft During the First Surgical Intervention Post-Injury

Contributing Authors: D Norman M Salai Noam Emanuel

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Synopsis

Non-union is a major concern in patients with long bone open fractures. Different strategies are available to reduce this risk, but high quality evidence remains elusive. The authors randomized 51 patients to receive PLEX-DBG (an antibiotic bone graft) or standard of care. Most patients had Gustilo III fractures. There was a significantly higher rate of callus formation in the PLEX-DBG group compa...