No Reduction in Pain or Opioid Consumption with Intra-Operative Ketamine vs Placebo in TKA
Intraoperative Ketamine in Total Knee Arthroplasty Does Not Decrease Pain and Narcotic Consumption: A Prospective Randomized Controlled TrialJ Arthroplasty. 2019 Aug;34(8):1640-1645.
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99 patients undergoing a primary unilateral total knee arthroplasty (TKA) were randomized to receive a 30mL infusion of ketamine or isotonic saline. The primary outcome of interest was pain as measured on a Visual Analog Scale (VAS). Secondary outcomes included narcotic consumption and the incidence of persistent opioid consumption. Results of the study revealed no significant differences in the a...
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