No difference in infection risk with single vs. multidose antibiotics in orthopedic implant surgery
Is There a Difference in Infection Risk Between Single and Multiple Doses of Prophylactic Antibiotics? A Meta-analysisClin Orthop Relat Res. 2019 Jul;477(7):1577-1590.
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14 studies (9691 patients) were included in this meta-analysis comparing single-dose antibiotics vs. multi-dose antibiotics for infection prophylaxis in patients undergoing an orthopedic procedure involving an implant placement. The primary outcome of interest was the incidence of surgical site infection. Results revealed no significant difference in the incidence of surgical site infection betwee...
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