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ACE Report #11955
Ace Report Cover General Orthopaedics

No difference in infection risk with single vs. multidose antibiotics in orthopedic implant surgery

Study Type:Meta-analysis/Systematic Review
OE Level Evidence:1
Journal Level of Evidence:1

Is There a Difference in Infection Risk Between Single and Multiple Doses of Prophylactic Antibiotics? A Meta-analysis

Clin Orthop Relat Res. 2019 Jul;477(7):1577-1590.

Contributing Authors: SP Ryan BJ Kildow TL Tan J Parvizi MP Bolognesi TM Seyler

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14 studies (9691 patients) were included in this meta-analysis comparing single-dose antibiotics vs. multi-dose antibiotics for infection prophylaxis in patients undergoing an orthopedic procedure involving an implant placement. The primary outcome of interest was the incidence of surgical site infection. Results revealed no significant difference in the incidence of surgical site infection betwee...

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