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No significant effect of peri-operative pregabalin on post-op pain and clinical outcomes after TKA
August 2019
No significant effect of peri-operative pregabalin on post-op pain and clinical outcomes after TKA
Study Type:Randomized Trial
OE Level Evidence:1
Journal Level of Evidence:2
Perioperative pregabalin does not reduce opioid requirements in total knee arthroplasty
Knee Surg Sports Traumatol Arthrosc. 2019 Jul;27(7):2104-2110.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
87 patients with osteoarthritis and scheduled for total knee arthroplasty (TKA) were randomized to receive oral peri-operative pregabalin or placebo for the reduction of opioid consumption and pain following surgery. The primary outcome of interest was cumulative morphine consumption during the first 72 hours post-operation. Secondary outcomes of interest included pain on a Visual Analog Scale (VA...
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