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No significant effect of peri-operative pregabalin on post-op pain and clinical outcomes after TKA
August 2019
No significant effect of peri-operative pregabalin on post-op pain and clinical outcomes after TKA
Study Type:Randomized Trial
OE Level Evidence:1
Journal Level of Evidence:2
Perioperative pregabalin does not reduce opioid requirements in total knee arthroplasty
Knee Surg Sports Traumatol Arthrosc. 2019 Jul;27(7):2104-2110.Synopsis
87 patients with osteoarthritis and scheduled for total knee arthroplasty (TKA) were randomized to receive oral peri-operative pregabalin or placebo for the reduction of opioid consumption and pain following surgery. The primary outcome of interest was cumulative morphine consumption during the first 72 hours post-operation. Secondary outcomes of interest included pain on a Visual Analog Scale (VA...
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