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ACE Report #11860
Ace Report Cover Arthroplasty

COA/ICORS2019: Topical vancomycin inferior to intravenous antibiotic prophylaxis in TKA

Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A

Is Topical Vancomycin an Option? A Randomized Controlled Trial to Determine the Safety of Topical Use of Vancomycin Powder in Preventing Post-Operative Infections in Total Knee Arthroplasty (TKA)

Contributing Authors: W Abuzaiter C Bolton A Hallan S Cartledge D Warchuk M Woolfrey

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


165 patients scheduled for total knee arthroplasty and administered preoperative intravenous antibiotic prophylaxis were randomized to either intraoperative topical vancomycin administration or twp postoperative intravenous antibiotic doses. The primary outcome of this study was incidence of surgical site infection. Results demonstrated a significantly higher incidence of surgical site infection i...

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