Oral vs. Intravenous Antibiotics for Bone and Joint Infection
Oral vs. Intravenous Antibiotics for Bone and Joint Infection
Oral versus Intravenous Antibiotics for Bone and Joint Infection
N Engl J Med. 2019 Jan 31;380(5): 425-436.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
1054 patients being treated for bone or joint infection at 26 UK centers were randomized in this non-inferiority trial to receive 6 weeks of oral antibiotic therapy (n=527) or 6 weeks of intravenous antibiotic therapy (n=527). The primary outcome of interest was the rate of definite treatment failure. Secondary outcomes of interest included the rate of treatment discontinuation, catheter complicat...
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