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Oral vs. Intravenous Antibiotics for Bone and Joint Infection

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Ace Report Cover
January 2022

Oral vs. Intravenous Antibiotics for Bone and Joint Infection

Vol: 163| Issue: 1| Number:1| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Oral versus Intravenous Antibiotics for Bone and Joint Infection

N Engl J Med. 2019 Jan 31;380(5): 425-436.

Contributing Authors:
HK Li I Rombach R Zambellas AS Walker MA McNally BL Atkins BA Lipsky HC Hughes D Bose M Kumin C Scarborough PC Matthews AJ Brent J Lomas R Gundle M Rogers A Taylor B Angus I Byren AR Berendt S Warren FE Fitzgerald DJF Mack S Hopkins J Folb HE Reynolds E Moore J Marshall N Jenkins CE Moran AF Woodhouse S Stafford RA Seaton C Vallance CJ Hemsley K Bisnauthsing JAT Sandoe I Aggarwal SC Ellis DJ Bunn RK Sutherland G Barlow C Cooper C Geue N McMeekin AH Briggs P Sendi E Khatamzas T Wangrangsimakul THN Wong LK Barrett A Alvand CF Old J Bostock J Paul G Cooke GE Thwaites P Bejon M Scarborough

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Synopsis

1054 patients being treated for bone or joint infection at 26 UK centers were randomized in this non-inferiority trial to receive 6 weeks of oral antibiotic therapy (n=527) or 6 weeks of intravenous antibiotic therapy (n=527). The primary outcome of interest was the rate of definite treatment failure. Secondary outcomes of interest included the rate of treatment discontinuation, catheter complicat...

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