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Paracetamol and ibuprofen, alone and in combination, for analgesia following total hip arthroplasty
May 2019
Paracetamol and ibuprofen, alone and in combination, for analgesia following total hip arthroplasty
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A
Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial
JAMA. 2019 Feb 12;321(6):562-571. doi: 10.1001/jama.2018.22039.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
559 patients scheduled for total hip arthroplasty were randomized to one of four groups for postoperative analgesia: paracetamol 1000mg plus ibuprofen 400mg, paracetamol 500mg plus ibuprofen 200mg, paracetamol 1000mg alone, or ibuprofen 400mg alone. Each group received their allocated treatment every 6 hours for a total of 4 doses over 24 hours. Primary outcomes included morphine consumption over ...
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