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AAOS2019: Statistical significance in RCTs may hinge on the outcome of a small number of patients
March 2019
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CONFERENCE ACE REPORTS
This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.
Synopsis
A review of a major orthopaedic journal (the Journal of Bone and Joint Surgery) was performed to identify randomized controlled trials published within the past 10 years which had reported a statistically significant finding for either a primary or secondary dichotomous outcome variable. The results from the identified articles were then subjected to a Fragility Index calculation. A total of 28 st...
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