Assessing the efficacy of opioids in management of chronic, noncancer pain
Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysisJAMA. 2018;320(23):2448–2460. doi:10.1001/jama.2018.18472
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96 randomized controlled trials were included in this meta-analysis and systematic review which sought to evaluate the efficacy and safety of opioid analgesia for chronic, noncancer pain compared to placebo and active comparator treatment. When compared to placebo, opioid therapy was associated with statistically significant effects with respect to pain relief, increase in physical function, and i...
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