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Meta-analysis
ACE Report #10862
Ace Report Cover General Orthopaedics

Assessing the efficacy of opioids in management of chronic, noncancer pain


Study Type:Meta-analysis/Systematic Review
OE Level Evidence:1
Journal Level of Evidence:N/A

Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis

JAMA. 2018;320(23):2448–2460. doi:10.1001/jama.2018.18472

Contributing Authors: S Ross JW Busse N Buckley L Wang DI Sessler X Sun LE Chaparro A Agarwal GH Guyatt S Ebrahimi E Chen S Schandelmaier A Kaushal PO Vandvik R Couban M Kamaleldin S Craigie JJ Riva L Montoya SM Mulla LC Lopes N Vogel K Kirmayr K De Oliveira L Olivieri I Oyberman L Tsoi T Lam S Hsu MM Bala A Scheidecker V Ashoorion Y Rehman PJ Hong BC Johnston R Kunz

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OE EXCLUSIVE

Synopsis

96 randomized controlled trials were included in this meta-analysis and systematic review which sought to evaluate the efficacy and safety of opioid analgesia for chronic, noncancer pain compared to placebo and active comparator treatment. When compared to placebo, opioid therapy was associated with statistically significant effects with respect to pain relief, increase in physical function, and i...

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