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RCT
ACE Report #10785
Ace Report Cover General Orthopaedics

Postoperative multi-dose oral versus IV TXA in total knee arthroplasty without tourniquet control


Study Type:Randomized Trial
OE Level Evidence:1
Journal Level of Evidence:N/A

Efficacy and safety of multiple boluses of oral versus intravenous tranexamic acid at reducing blood loss after primary total knee arthroplasty without a tourniquet: A prospective randomized clinical trial

Thromb Res. 2018 Nov;171:68-73. doi: 10.1016/j.thromres.2018.09.054

Contributing Authors: FX Pei Q Huang G Chen J Xie Z Huang Y Lei G Cao H Xu

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Synopsis

118 patients scheduled for total knee arthroplasty without a tourniquet and intravenous tranexamic acid administration prior to incision were randomized to three postoperative doses of either 2g oral tranexamic acid or 1g intravenous tranexamic acid. Patients were assessed primarily for drop in hemoglobin and hematocrit levels, as well as for secondary outcomes of total blood loss, hidden blood lo...

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