Postoperative multi-dose oral versus IV TXA in total knee arthroplasty without tourniquet control
Efficacy and safety of multiple boluses of oral versus intravenous tranexamic acid at reducing blood loss after primary total knee arthroplasty without a tourniquet: A prospective randomized clinical trialThromb Res. 2018 Nov;171:68-73. doi: 10.1016/j.thromres.2018.09.054
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118 patients scheduled for total knee arthroplasty without a tourniquet and intravenous tranexamic acid administration prior to incision were randomized to three postoperative doses of either 2g oral tranexamic acid or 1g intravenous tranexamic acid. Patients were assessed primarily for drop in hemoglobin and hematocrit levels, as well as for secondary outcomes of total blood loss, hidden blood lo...
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