Periprosthetic bone loss post-total hip arthroplasty mitigated by bisphosphonate therapy

Study Type:Meta analysis

OE Level Evidence:1

Journal Level of Evidence:N/A

Effects of bisphosphonates in preventing periprosthetic bone loss following total hip arthroplasty: a systematic review and meta-analysis

J Orthop Surg Res. 2018 Sep 4;13(1):225. doi: 10.1186/s13018-018-0918-7

Contributing Authors: G Liang J Shi R Huang L Liao D Qin

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Synopsis

12 randomized controlled trials were included in this meta-analysis which sought to evaluate the effect of bisphosphonate therapy in reducing loss of periprosthetic bone mineral density after total hip arthroplasty. In pooled analyses, reduction of periprosthetic bone mineral density was smaller among BP groups compared to control groups within 1 year of surgery, at 2-4 years after surgery, and at...